![]() As always, we strive to provide valuable content and foster a positive gamingĬommunity. We appreciate your understanding and support in our commitment to upholding legal and ethical This is the Ghost Squad Nintendo WII Game guaranteed to work like new and backed. These platforms not only ensure that the creators receive the recognition theyĭeserve but also enable you to play with enhanced features and support ongoing game Buy Ghost Squad the Nintendo Wii Game now on Sale with Free Shipping. Re-releases are some of the exciting avenues that offer legitimate ways to relive nostalgic Officially licensed emulators, digital distribution services, and console Moreover, various platforms have emerged that provide legal access to retro gamingĮxperiences. You to build your personal collection and support the industry you love. In fact when it was converted to the Wii in 2007 some observers uncharitably. They offer a wide selection of classic games, allowing Some simply aspire to be fun: and that's the kind of game Ghost Squad is. One such option is purchasing original copiesįrom reputable sources like Amazon. Legal alternatives for enjoying retro games. The ROMs, we hope to encourage the appreciation and purchase of legitimate copies.Īlthough our ROMs are no longer available, we would like to emphasize that there are numerous However, we firmly believe in supporting the creators andĭevelopers who have put their hard work into crafting these incredible games. ![]() We understand that this change may come as a surprise to some of you who have been enjoying This decision was made inĪlignment with our commitment to respect copyright laws and promote ethical practices within As of today,Īll ROM files have been completely removed from our platform. We want to take a moment to address an important update regarding our website. Welcome Nintendo Wii Shooter Ghost Squad Ghost Squad (Nintendo Wii) Release Date: Format: NTSC-U/C Add to wishlist Publisher: SEGA Genre: Action & Adv, Shooter Platform: Nintendo Wii Rating: Teen New New Usually ships within 24 hours Price: 29.95 MSRP: 39.99 Notify Me Used Used - complete Usually ships within 24 hours Price: 10. ![]() If you're looking for a challenging shooter game for the Wii, then Ghost Squad is the game for you. The game features intense action, realistic settings, and a wide variety of weapons, allowing you to customize your Ghost Squad for the ultimate in combat prowess. In conclusion, Ghost Squad is a great action-packed shooter game for the Nintendo Wii. Additionally, the game features an array of customizable weapons, such as assault rifles, machine guns, and shotguns, as well as an array of special abilities to boost your Ghost Squad's proficiency. The action is fast-paced and the graphics are quite impressive for a game on the Nintendo Wii. The game itself is quite intense, as players must face relentless waves of enemy forces in a variety of realistic settings. Players take on the role of a Ghost Squad, outfitted with a host of high-tech weaponry, and tasked with global missions to protect the world from terrorist threats. Ghost Squad is an action-packed shooter game designed and developed exclusively for the Nintendo Wii. ![]()
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![]() ![]() Maggie Smith is also excellent, playing the stern Mother Superior with a sprinkle of sass. It’s typical fish-out-of-water fare, but the real joy comes as she makes over the convent’s dismal choir and the nuns come out of their shells. Whoopi Goldberg camped it up in this uplifting comedy, playing a singer who winds up in a San Francisco convent after being put into witness protection. It’s all screamingly camp, but undergirded by a hotbed of raw jealousy from Roberts that culminates in perhaps cinema’s greatest – read: most cringe-inducing – karaoke scene. The piano scene, in one of those lavish toy stores that only exist in films of this period, is by now a modern classic.įood critic Julia Roberts belatedly decides she’s madly in love with her best mate (Dermot Mulroney) and tries to break up his engagement to the most good-natured woman on earth, Cameron Diaz’s Kimberly, in PJ Hogan’s romcom. This allows adult Josh (Tom Hanks) to goof around charmingly. Then, by magic, he becomes one – physically, at any rate, as he still has the mind of a child. Thirteen-year-old Josh (David Moscow) wishes that he were a grown-up. Identity-switch comedies are ten-a-penny, but this remains fresh, smart and one of the sweetest of them all. All seven episodes will be on iPlayer on Saturday. Just to prove that director Christopher Nolan wasn’t the first to be fascinated by the inventor of the atomic bomb, a rare chance to catch this triple Bafta-winning (and Emmy nominated) drama from 1980, starring the estimable Sam Waterston as the physicist, who was famously plagued by regrets. We’re taken from the 1840s, when the fast-growing Royal family inspired her to add a new wing, balcony and raft of servants, to Prince Albert’s premature death in 1861. ![]() Tonight, Elizabeth (Alicia von Rittberg) faces another loyalty test when the court is shocked by her stepsister Mary’s (Romola Garai) defiance but that’s nothing compared to the dilemma she faces when Seymour (Tom Cullen) makes a series of missteps.īuckingham Palace with Alexander ArmstrongĪlexander Armstrong continues his fascinating look at the historic palace by exploring the ups-and-downs of Queen Victoria’s time there. The slick costume drama set during Elizabeth I’s teenage years continues with a double bill. Later at 12.55am, The Everly Brothers: Harmonies from Heaven examines their Appalachian upbringing. Ahead of their 1983 reunion concert at the Royal Albert Hall (10.35pm), director Anthony Wall traces the brother’s influence on a generation of stars. This vintage edition of the BBC’s flagship arts series traces the rise, acrimonious split and reunion of two early giants of rock’n’roll, Don and Phil Everly. The Everly Brothers: Songs of Innocence and Experience: Arena Strictly’s Anton Du Beke is among those gracing the Pointless podium, along with EastEnders actress Emma Barton, saxophonist YolanDa Brown, antiques expert Eric Knowles and The Repair Shop’s Will Kirk. The two-part docu-series about the late Queen’s life prior to her accession to the throne concludes by covering her marriage to Prince Philip in 1947, the birth of her two eldest children and her fateful, life-altering trip to Kenya in 1952. That there was far more to Anne besides (she set a number of key royal precedents, such as making her husband prince consort rather than king) is celebrated in an enthusiastically fascinating documentary. Principally the 1707 Act of Union, which united England and Scotland for the first time, ensured the Protestant succession and made Anne the first monarch of Great Britain. “It’s time to change the narrative,” says Dr Tracy Borman, one of many historians and authors (including Alice Loxton) arguing Anne’s case here – and rightly so, as she reigned over a period that saw some of the most complex political changes ever to occur on these islands. However, her regal achievements are rarely acknowledged. Anne, who reigned from 1702 to 1714, is mostly remembered for her childbearing tragedies, the death of her 11-year-old sole heir Prince William and the later-in-life scandal surrounding the vicious rivalry between two of her ladies in waiting (which in turn inspired the 2018 Oscar-winning film The Favourite). Widely regarded as something of a side note to British history, Queen Anne is undergoing a welcome reassessment. ![]() ![]() The warning of his assassination also foreshadows it. Such carelessness helps foreshadow Caesar's death in an ironic way. With his ego so inflated, Caesar is unable to recognize a warning when it is blatantly given to him. Caesar brushes off the soothsayer's words and doesn't give them a second thought. What makes it especially important is Caesar's reaction. What does it mean? A soothsayer warns Julius Caesar about his impending assassination in this pivotal scene. Alea was a game played with a die or dice rather than the actual dice themselves, so another translation might be "The game is afoot."Beware the ides of March." (Act I, Scene II, line 23) Suetonius' subtly different translation is often also quoted as alea iacta est. Suetonius gives the Latin version, iacta alea est, although according to Plutarch's Parallel Lives, Caesar quoted a line from the playwright Menander: "ἀνερρίφθω κύβος", anerríphthō kȳbos, "let the die be cast". ^ Lives of the Caesars, "Divus Julius" sect.The Epic Saga of Julius Caesars Tenth Legion and Rome. ^ "How Julius Caesar Started a Big War by Crossing a Small Stream".the exact date is not known, nor even the location of this most historically significant of rivers". "Sometime around 10 January 49 BCE, Julius Caesar. ![]() Caesar's decision for swift action forced Pompey, the consuls, and a large part of the Roman Senate to flee Rome. The phrase "crossing the Rubicon" has survived to refer to any individual or group committing itself to a risky or revolutionary course of action, similar to the modern phrase "passing the point of no return". Īccording to Suetonius, Caesar uttered the famous phrase ālea iacta est ("the die has been cast"). It was reported that Caesar dined with Sallust, Hirtius, Oppius, Lucius Balbus and Sulpicus Rufus on the night after his famous crossing into Italy on 10 January. Roman historian Suetonius depicts Caesar as undecided as he approached the river and attributes the crossing to a supernatural apparition. In doing so, he deliberately broke the law on imperium and made armed conflict inevitable. Julius Caesar led a single legion, Legio XIII, south over the Rubicon from Cisalpine Gaul to Italy to make his way to Rome. Julius Caesar Julius Caesar, depicted as pausing on the banks of the Rubicon Generals were thus obliged to disband their armies before entering Italy. If a general entered Italy in command of an army, both the general and his soldiers became outlaws and were automatically condemned to death. Furthermore, obeying the commands of a general who did not legally possess imperium was a capital offense. ![]() Any magistrate who entered Italy at the head of his troops forfeited his imperium and was therefore no longer legally allowed to command troops.Įxercising imperium when forbidden by the law was a capital offense. Roman law specified that only the elected magistrates ( consuls and praetors) could hold imperium within Italy. The governors then served as generals of the Roman army within the territory they ruled. Governors of Roman provinces were appointed promagistrates with imperium (roughly, "right to command") in one or more provinces. On the northwestern side, the border was marked by the river Arno, a much wider and more important waterway, which flows westward from the Apennine Mountains (its source is not far from the Rubicon's source) into the Tyrrhenian Sea. According to some authors, he uttered the phrase alea iacta est ("the die is cast") before crossing.ĭuring the late Roman Republic, the river Rubicon marked the boundary between the Roman province of Cisalpine Gaul to the northeast and Italy proper (controlled directly by Rome and its allies) to the south. As it was illegal to bring armies into Italy (the northern border of which was marked by the river Rubicon) his crossing the river under arms amounted to insurrection, treason, and a declaration of war on the state. As his term of governorship ended, the Senate ordered him to disband his army and return to Rome. Caesar had been appointed to a governorship over a region that ranged from southern Gaul to Illyricum. His crossing of the river precipitated Caesar's civil war, which ultimately led to Caesar's becoming dictator for life ( dictator perpetuo). ![]() Scholars usually place it on the night of 10 and 11 January because of the speeds at which messengers could travel at that time. Its meaning comes from allusion to the crossing of the river Rubicon by Julius Caesar in early January 49 BC. The phrase " crossing the Rubicon" is an idiom that means "passing a point of no return". The modern Rubicon river (dark blue), believed to be the same river crossed by Caesar Look up cross the Rubicon in Wiktionary, the free dictionary. ![]() ![]() Join Todayĩ - Microphone indicator in macOS: Starting with macOS Monterey, users can also see which apps have access to their Mac's microphone in the Control Center. ![]() Worried about insider threats? We've got you covered! Join this webinar to explore practical strategies and the secrets of proactive security with SaaS Security Posture Management. Shield Against Insider Threats: Master SaaS Security Posture Management What's more, Safari now "automatically upgrades sites known to support HTTPS from insecure HTTP."ħ - App Privacy Report: Similar to the new Privacy dashboard Google introduced in Android 12, this new section in Settings lets users check how often apps have accessed sensitive data such as location, photos, camera, microphone, and contacts during the last seven days, in addition to highlighting "which apps have contacted other domains and how recently they have contacted them." App Privacy Report is set to arrive as part of a future software update to iOS 15, iPadOS 15, and watchOS 8 later this year. And it prevents senders from seeing if you've opened their email."Ħ - Improved Intelligent Tracking Prevention: Intelligent Tracking Prevention, which is Apple's privacy feature aimed at reducing fingerprinting and cross-site tracking on Safari, is getting stronger protections by also hiding the user's IP address from trackers, thereby curtailing their ability to utilize the user's IP address as a unique identifier to connect their activity across websites and build a profile about them. Should users choose to turn the feature on, "it hides your IP address so senders can't link it to your other online activity or determine your location. ![]() When an email containing an invisible pixel is opened, the image connects to the sender's server, while also funneling back sensitive data like users' IP address, device location, and the email client used. A tracking pixel - typically a single-pixel image - is how marketers know whether an email gets opened. Apple already offers a similar feature through Sign In With Apple.ĥ - Mail Privacy Protection: Apple is taking on the invisible tracking pixels embedded in emails with its new Mail Privacy Protection feature. The feature, however, will not be available in China, Belarus, Colombia, Egypt, Kazakhstan, Saudi Arabia, South Africa, Turkmenistan, Uganda, and the Philippines due to regulatory reasons.Ĥ - Hide My Email: Also included as part of the iCloud+ bundle and built into Safari and Mail apps, the feature enables the ability to generate one-off burner emails when signing up for a service on the web without having to give away the actual email address. This separation of information protects the user's privacy because no single entity can identify both who a user is and which sites they visit." The second decrypts the web address they want to visit and forwards them to their destination. "The first assigns the user an anonymous IP address that maps to their region but not their actual location. ![]() ![]() "All the user's requests are then sent through two separate internet relays," Apple says. The feature ensures that traffic leaving the device is encrypted before forwarding the requests through two internet relays, thus creating a simplified version of Tor, which employs at least a minimum of three relays to achieve anonymity. Unlike traditional VPNs who are still privy to users' real IP addresses and the websites they visit, iCloud Private Relay employs a dual-hop architecture that effectively shields IP address, location, and browsing activity that can be used to create a detailed profile. 3 - Private Relay: To come as part of Apple iCloud+ for existing iCloud subscribers at no extra cost, Private Relay is akin to a VPN in that it routes users' internet traffic on Safari browser through two relays in order to mask who's browsing and where that data is coming from. ![]() ![]() Upload, livestream, and create your own videos, all in HD. Welcome to our YouTube channel, where we bring you the best pranks, gags, and laughs on the internet Our team of comedians and creators are dedicated to bringing you hilarious and entertaining. New intro for PranK Invasion a big cool channel youtube.Animation & design by fxchannelhouseNeed a new Branding - pm me for custom projects. Ogni giorno: Live Music, After Beach Partys, Eventi esclusivi, Games, Tornei Sportivi, Party Boat and so much more. While the organization has not officially commented, his fans (yes, he has fans, unfortunately) have already risen up against the WNBA, filling their Instagram posts with spam and indecent phrases that I won’t repeat here out of decency. 72 ore party no stop Questo quello che troverai allo Spring Break Invasion. Shortly after, he realized the consequences when security finally kicked him out and informed him that his presence “was not allowed on the premises.” And it wasn’t just at WNBA games, but “all NBA-related events” as well. Don’t think that this guy is a teenager – he’s old enough not to be engaging in such foolishness. When the security department warned him, he lied, claiming he had a medical condition that forced him to fall asleep. Last Thursday, JiDion attended a Los Angeles Sparks game in his pajamas (more comedy, apparently!). But as if first-rate comedy wasn’t enough, shortly after, he tried to double down on being the least amusing person on the face of the Earth. What Ever Happened To Prank Invasion SunnyV2 3.3M subscribers Subscribe 1.8M views 2 years ago MERCH - There are few that carry a reputation as infamous as Chris. User Summary Future Projections Detailed Statistics Featured Box Similar Channels User Videos Live. ![]() We know all this because he himself uploaded the videos in an unparalleled display of ego. seriously though, the videos follow a premise of this fugly guy walking up to hot women who aren't paid actors and saying shit like 'if you lose this game then you gotta kiss me' and he makes out with this non paid actor for minutes and kids find it hot. Our Black Friday/Cyber Monday Sale is live Best deal of the year Take 75 off all credits until the end of the day Cyber Monday (28th) with code BFCM2022. Provides a report on the performance of the prank invasion channels subscriber ranking, average views, Super Chat revenue, and paid advertising content. In fact, he went to a Minnesota Lynx game where he pretended to sleep, and when the ball came to him after a rebound, instead of returning it sportsmanlike, he attempted to take a shot, failing miserably. If you find this funny, honestly, you should reconsider. It’s basically just a dude named Chris who makes videos that revolve around getting supposedly random girls. ![]() The idea of this so-called joke was as follows: he would go to women’s basketball games and pretend to fall asleep, occupying three seats, thus trying to humiliate both the players and their fans. It’s not exactly what you’d expect from a YouTube channel called Prank Invasion. This is the case of JiDion, a YouTuber who had prepared the least amusing prank you could imagine, with the sole intention of, well, displaying his misogyny in public. ![]() ![]() Many theories on this exist, and they may not be mutually exclusive. During their quest they encounter many evils and dark magic, but in spite of all this she never gives up hope because unlike her brother she doesn’t have a choice Why did JRR Tolkien choose to create his female characters to be behind their male counterparts? After finding out about a potential second bearer of the One Ring, she goes on a quest with a group in order to find it before Sauron does. She struggles to forgive herself for not protecting her brother more and believes that she deserves her fate. A strong and intelligent person who has learnt from her mistakes. Isildur’s sister, created for the series. She had three children with him: Elladan, twin brother to Elrohir Elrohir himself and another daughter named Anairë.Įma Horvath as Eärien: Isildur’s sister – The Lord of the Rings: The Rings of Power How does she reflect Tolkien’s view on women? After their wedding, they lived at Imladris for a time. She married one Elrohir of Gondolin, son of Eärendil the Mariner and Elven Princess Idril Celebrindal. In addition to her brief mention in Tolkien’s Unfinished Tales (chapter 10), she is described briefly in Appendix A: The Tale of Aragorn and Arwen from Return of the King, which says that she was born in Rivendell thirty-five years before her elder brother, Isildur. Who is Eärien?Įärwen, daughter of Elrond and Celebrían, is an elf who appears in various texts. A short summary of events in order of appearance in season one that covers who they are, where they came from, their major arc, and what happened to them at season one’s end (the first death is also noted). Read my impressions of the adaptation, along with my critique on some aspects I like and dislike. Watch the series to get a feel for the lore and background. In the end, when they are both in hiding after the show ends, Ema admits to him that it was in fact Xanax.ġ. He then offers her heroin but she declines. Baldry later asks if it was Xanax, which Ema denies. When she gets the job, she tells Baldry I’m not just some junkie. In one scene she takes a pill before going to her job interview. She smokes a lot and has some form of drug addiction. One way that Ema is shown to be like her brother is through having an addictive personality. When Isildur stole the Ring of Power, he left it in Rivendell when he fled Mordor at night. However, they loved each other deeply despite everything that was going on between them. And this is why they couldn’t get along, because they felt like they were in competition with one another. Unlike their father and most generations before them, both were born with a heavier set of expectations to fulfill. As children, both siblings wanted to be different from one another, but the full burden of destiny came too early for them. Isildur and Eärien had a tumultuous relationship with each other. Why there is so much angst between the siblings We have great memories from our time together. We bonded over bungee jumping and zip-lining together in New Zealand, says Baldry. For many years now, she has been living with Baldry as his girlfriend. They are happy, they are free and there is nothing else that I would rather see. I love watching them come off the field with smiles on their faces. Today, Ema enjoys rugby for a slightly different reason. She soon followed him into rugby, and even competed in both U20s and Seniors with Richmond. When she was six years old, Ema used to watch her little brother play rugby on a Sunday. For example, he won’t tolerate violence or drinking alcohol. He is an elf who takes care to keep Tolkien’s elves on Middle-earth true to their nature and not make them into orcs. Ema Horvath plays a character named Eärien in The Lord of the Rings: The Rings of Power. The story is centered on the powerful magic rings forged by the Elves, but also follows an imaginative journey with characters like hobbits, elves, men and dwarves. Tolkien’s Eärien: The Forgotten She-Elf of Middle-EarthĪbout The Lord of the Rings: The Rings of Power Why did JRR Tolkien choose to create his female characters to be behind their male counterparts?.How does she reflect Tolkien’s view on women?.Why there is so much angst between the siblings. ![]() About The Lord of the Rings: The Rings of Power. ![]() ![]() ![]() They might just sound like different workspaces but there’s a bit more to them than that. Image credit: Rod LawtonĪffinity Photo is organised into a series of different ‘Personas’ according to what you want to do and the tools you need. Image credit: Rod Lawton The Tone Mapping Persona is so good at HDR, both stylized and subtle, that you may never want to use anything else. Usability and interface The Develop Persona now offers the option to output the processed image to a RAW Layer, which means you will be able to change the RAW processing settings at will further down the line. It’s a multi-discipline crossover tool for artists, designers and illustrators, not just photographers, in exactly the same way that Photoshop is. It has an excellent inpainting brush for object removal, powerful selection and masking tools and both natural brush media tools and vector drawing and type layers too. ![]() Another is its Live Filters, which can be added non-destructively as layers and manipulated live on the image. One is a set of tone mapping tools which are much better at realistic or hyper-real HDR effects than Photoshop’s. Like Photoshop, this is software designed for people who know what they want to do and don’t need any ideas from their software.Īffinity Photo 2 does have some notable power features. There is no library of presets and no means of creating your own. ![]() It’s also not designed for instant effects and ‘looks’. It is an extremely powerful photo editor that matches Photoshop feature-for-feature and even beats it in many areas.īut it also lacks any kind of browsing or cataloguing tools, and there are none across the whole Affinity suite, not even something as basic as Adobe Bridge. Perhaps the most important thing to note about Affinity Photo is that it’s just like Photoshop – and lacks all the things that Photoshop lacks. Image credit: Rod Lawton Live Filters are one of Affinity Photo’s party tricks – it can apply lightning effects live, for example, in a non-destructive layer you can modify at any time. Image credit: Rod Lawton The Develop Persona’s Detail Refinement option does a remarkable job of enhancing detail without artefacts. Key features Affinity Photo 2 has powerful RAW processing tools to rival those in Adobe Camera Raw, but it’s integrated into Affinity Photo, not a separate tool. There is also an Affiinity Photo for iPad edition, which I reviewed some time back, which is remarkably powerful for a tablet app and feels more ‘finished’ than Photoshop for iPad. What’s more, at the time of writing, Affinity is continuing a 40% off introductory offer which means Affinity Photo 2 is just $40.99/ £35.99 to buy. And although all three have had a slight price increase, they are still dramatically cheaper to buy/own than their Adobe rivals. I have written a separate Affinity Photo 2 review in Amateur Photographer if you want to check that one out.Įssentially, the three Affinity applications are rivals to Adobe Photoshop, Illustrator and InDesign, but without the Adobe subscription.They can all be used individually but have been designed to work together too, and have recently been updated across the board and relaunched as Version 2. Affinity Photo 2 is one of a trio of professional creative applications under the Affinity brand, which also includes Affinity Designer and Affinity Publisher. ![]() ![]() ![]() ![]() International orders will pay a duty fee upon delivery so please provide a phone number. These are custom made by hand to order with individual care put into every one. mercenary Howling Commandos unit and aiding with Winter Soldier (Bucky Barnes)'s missions. This Captain America Shield is only made from quality parts and built for people who are looking for a premium shield a step above the rest. AS ZOMBIE JASPER SITWELL WAS AN EARLY agent of S.H.I.E.L.D. It measures 24 inches across, weighing around 6 pounds. INSPIRED BY MARVEL ENTERTAINMENT: This blue and white Captain America Stealth Shield is inspired by the gear that appears with Captain America in Marvel movies. Marvel Legends Series Captain America: The Winter Soldier Stealth Shield -Adult Fan -Costume and Collectible, Ages 14 and Up 413 100+ viewed in past week 10995 List: 127. The Story of Marvel Studios: The Making of the Marvel Cinematic Universe explores how the events of The Winter Soldier affected Agents of SHIELD, revealing a fascinating detail. ![]() Related: Why The Ten Rings Organization Is More Dangerous Than Hydra. The Straps are made from durable and thick leather regularly used in the 1940's, and are mounted to specially machined aluminum brackets and buckles. An authentic replica of the prop used in Avengers: Endgame and The Falcon and the Winter Soldier. Marvel Legends Series Captain America: The Winter Soldier Stealth Shield -Adult Fan -Costume and Collectible, Ages 14 and Up. 1-48 of 121 results for 'captain america winter soldier shield' Results Price and other details may vary based on product size and color. SHIELD, unfortunately, collapsed in an official capacity. The star is top quality comparing only to the original. Marvel Legends The Falcon and The Winter Soldier Captain America premium role-play shield is a notable addition to any Marvel fan collection. It is made of 1/8 aluminum with grooves in between the rings just like the real one. It is a great weight for walking around conventions with. It measures 24 inches across, weighing around 6 pounds. Marvels Captain America Shield - 'The Falcon And The Winter Soldier' Shield - Metal Prop Replica - Cosplay And Role Play - Halloween Costume. This shield is also battle damaged after Captain America's long battles with his devious foes. The brown leather straps on the back are made to hold the weight of the. Screen Accurate Metal Captain America Shield Replica for Cosplay and Display.Īn authentic replica of the prop used in "Captain America: The Winter Soldier". Just like the prop from the movie, we use a blue instead of red for the outer rings. An Upgraded Shield for an Upgraded Cap, Marvel Studios prop master Russell Bobbitt revealed why Captain America's shield design was altered at the end of Avengers: EndgameThe Falcon and the Winter Soldier in order to add five detailed points engraved on the star and on the gray outer rim. It has been treated to an almost mirror finish. ![]() ![]() ![]() The dilute thrombin time (dTT) and ecarin clotting time (ECT) have both been suggested as better laboratory parameters for this purpose. 3,4 As a result, maximum assay levels (>200 sec) are often achieved before reaching therapeutic levels of dabigatran, making it a suboptimal test. 3 Another assay, thrombin time (TT), has a dose-dependent prolongation with dabigatran however, it is exquisitely sensitive to low levels of the drug. This may be due to the high concentration of tissue factor in PT reagents, resulting in activation of the coagulation cascade and production of additional Factor Xa and thus thrombin. With regard to assays available to monitor the anticoagulant activity of dabigatran, while prothrombin time (PT) and international normalized ratio (INR) are commonly used to monitor warfarin-mediated anticoagulation, they have significant variability in monitoring direct thrombin inhibitors such as dabigatran. 2,3 It is primary renally-excreted (80%), an important consideration in patients with chronic renal impairment. 3 The half-life of dabigatran is 12-17 hours, warranting twice-daily dosing. 2 Its activity peaks between 30-120 minutes after administration and rapidly decreases by approximately 70% over four to six hours. Dabigatran is a prodrug, requiring hydrolysis to become active it binds to both free and clot-bound thrombin. This article reviews the current literature on reversing dabigatran function, with special focus on idarucizumab and the Reversal of Dabigatran Anticoagulant Effect With Idarucizumab (RE-VERSE AD) trial.Ī few key points on dabigatran's formulation and pharmacokinetics are critical to this discussion. However, recent studies have shown promise of specific reversal agents for various NOACs, including dabigatran. Although dabigatran and the other NOACs have been extremely useful in the clinical setting, two major clinical issues remained unsettled: the lack of a reliable reversal agent, and difficulty with laboratory monitoring due to inter-patient variability in commonly assayed coagulation parameters. Food and Drug Administration (FDA) in 2010, with indications broadened to the prevention and treatment of VTE. In 2008, the European Commission approved dabigatran etexilate, a reversible direct thrombin inhibitor, for stroke and systemic embolization risk reduction in patients with non-valvular AF it was subsequently approved by the U.S. These drugs were developed to eliminate the need for routine blood monitoring with anticoagulants such as warfarin, and to achieve standard drug dosing with predictable pharmacokinetics. ![]() Pradaxa was the first in a new crop of blood clot and stroke-prevention drugs meant to replace warfarin, a half-century-old pill that requires frequent blood monitoring, carries serious bleeding risks and has dietary and lifestyle restrictions.Over the past decade, novel oral anticoagulants (NOACs) have become more commonly used for prevention of venous thromboembolism (VTE), and management of stroke risk in patients with atrial fibrillation (AF). It works by blocking thrombin, a blood enzyme involved with clotting. Pradaxa, also known as dabigatran, was approved in 2010 to prevent strokes in patients with atrial fibrillation, an irregular heartbeat that affects more than 2.5 million American adults and which raises the risk of stroke fivefold. Stephan Glund, a research executive of privately held Boehringer Ingelheim Pharmaceuticals, the German drugmaker that developed Pradaxa and is testing the antidote. “These are absolutely exciting findings,” said Dr. Dallas, Nov 18 (Reuters) - An experimental antidote to the widely used blood clot preventer Pradaxa worked immediately and completely in an early-stage trial among healthy volunteers, raising hopes that the drug’s blood-thinning effects can be reversed in emergency situations. ![]() ![]() ![]() You can also convert each of those file types to PDF.īasic as it may be, Smallpdf can add pages to or compress existing PDF documents. These include tools for converting PDF files to Word, Excel, PowerPoint and JPEG. Smallpdf's free online PDF editing offering is super-basic, only making it possible to add minor changes to documents.īut you may find Smallpdf's other free features more compelling. All the other tools work as expected, including a signature tool that lets you sign a document using the keyboard, your mouse or an uploaded image. You can add a new text field to your document, enter new text and adjust the text, placing it anywhere you want on the document.īut there is no way to make changes to existing text, other than by redacting it. You have four fonts to choose from, but you can resize those fonts to almost any level you want, and you can also make changes to text colors and styles. ![]() Drag a file to your browser - there's a 10MB max size - then use FormSwift's tools to add new text and images highlight, redact or erase existing text and sign documents.įormSwift's text tools are limited. Or you can download blank versions of the documents and enter information locally on your computer.įor PDF editing, the process is simple. We found FormSwift's offerings to be excellent and well worth a look if you need basic business documents such as 1099s, lease agreements and business meeting minutes.Īll of these forms can be filled out online and downloaded once you've added the pertinent information. While it gives you the option to upload and edit PDF files, it also offers a large library of legal and other business forms you can fill in online and download as a PDF file or Word document. Preview is a solid option for basic PDF editing, and if you own a Mac, accessing Preview's powers is as simple as launching the app.įormSwift offers a slightly different twist on PDF editing. Those markup tools include text-selection options drawing tools you can use to add freehand drawings to a document a text tool for adding additional text to a document a tool that adds shapes and notes and a signature tool that you can use to capture your signature using your Mac's camera, a tablet or your trackpad. Preview's full set of markup tools appears when you click a small markup button that looks like a pencil tip located next to the search tool in the Preview toolbar. The bulk of Preview's markup capabilities aren't obvious when you first open the app, although you'll find a few basic tools for rotating pages and highlighting text on the basic toolbar. It is the multitool of the image-editing universe, capable of opening virtually any image file you may encounter. Not only is it capable for working with PDF files, but it also offers a number of other image-editing features. Apple's Preview application is built into every version of macOS. ![]() |
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